Abstract from the PDF :
Pierre Fabre presents in this quality paper its capabilities in Active Pharmaceutical Ingredient Improvements.
The company presents 2 processes to enhance the dissolution rate/solubility of APIs, the main objective being the bioavailability enhancement.
Nano–particles and FORMULPLEX® technologies for enhancement of bioavailability
of poorly soluble drug
"About two thirds of the products used in the pharmaceutical industry are in solid form, such as tablets and pills. Consequently a lot of effort has been put into research on
particle generation processes. The standard processes, crushing/milling and crystallisation/precipitation, are still the most commonly used.
However, supercritical fluid (SCF) technology presents a new and interesting route for particle formation, which avoids most of the drawbacks of the traditional methods.
Supercritical processes give micro- or even nano-particles with a narrow size distribution. It can also be used in co-process with excipients or host molecules like
cyclodextrins". |
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